GPUDirect technology from NVIDIA facilitates direct data exchange between multiple GPUs, third-party network adapters, solid-state drives, and other PCIe devices. GPUDirect allows for peer-to-peer transfers between GPUs and remote direct memory access (RDMA), ideal for High-Performance Computing (HPC) and Machine Learning (ML) applications. P2P transfers enable data exchanges between two GPUs on a host without relying on host memory, easing the burden on the host CPU, while multi-host RDMA allows a Host Channel Adapter (HCA) to directly read and write GPU memory data buffers and transfer the data through a remote HCA to a GPU on another host, bypassing host memory and reducing host CPU involvement. Both approaches exhibit significant performance improvements for GPU accelerated HPC and ML/DL applications.